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Article

Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy.

eLife - 12 Jul 2024

Zambo Boglarka, Edelweiss Evelina, Morlet Bastien, Negroni Luc, Pajkos Matyas, Dosztanyi Zsuzsanna, Ostergaard Soren, Trave Gilles, Laporte Jocelyn, Gogl Gergo

Abstract excerpt

Truncation of the protein-protein interaction SH3 domain of the membrane remodeling Bridging Integrator 1 (BIN1, Amphiphysin 2) protein leads to centronuclear myopathy. Here, we assessed the impact of a set of naturally observed, previously uncharacterized BIN1 SH3 domain variants using conventional in vitro and cell-based assays monitoring the BIN1 interaction with dynamin 2 (DNM2) and identified potentially...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myopathies, Structural, Congenital

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Identifiers

PMID: 38995680
DOI: 10.7554/eLife.95397
PMCID: PMC11245310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy.PMID 38995680Read ↗

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