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Article

Tamoxifen improves muscle structure and function of Bin1- and Dnm2-related centronuclear myopathies.

Brain : a journal of neurology - 3 Jul 2023

Gineste Charlotte, Simon Alix, Braun Marie, Reiss David, Laporte Jocelyn

Abstract excerpt

Congenital myopathies define a genetically heterogeneous group of disorders associated with severe muscle weakness, for which no therapies are currently available. Here we investigated the repurposing of tamoxifen in mouse models of mild or severe forms of centronuclear myopathies due to mutations in BIN1 (encoding amphiphysin 2) or DNM2 (encoding dynamin 2), respectively. Exposure to a tamoxifen-enriched diet...

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Identifiers

PMID: 36562127
DOI: 10.1093/brain/awac489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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