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Article

A range of 30-62% of functioning multiciliated airway cells is sufficient to maintain ciliary airway clearance.

The European respiratory journal - 1 Oct 2024

Loges Niki T, Marthin June Kehlet, Raidt Johanna, Olbrich Heike, Höben Inga M, Cindric Sandra, Bracht Diana, König Julia, Rieck Cynthia, George Sebastian, Kloth Tim Luis, Wohlgemuth Kai, Pennekamp Petra, Dworniczak Bernd, Holgersen Mathias G, Römel Jobst, Schmalstieg Christian, Aprea Isabella, Mortensen Jann, Nielsen Kim G, Omran Heymut

Abstract excerpt

BACKGROUND: Primary ciliary dyskinesia is a genetic disorder caused by aberrant motile cilia function that results in defective ciliary airway clearance and subsequently leads to recurrent airway infections and bronchiectasis. We aimed to determine: how many functional multiciliated airway cells are sufficient to maintain ciliary airway clearance? METHODS: To answer this question we exploited the molecular...

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Identifiers

PMID: 38991708
DOI: 10.1183/13993003.01441-2023
PMCID: PMC11469306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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