Article

Copper impedes calcification of human aortic vascular smooth muscle cells through inhibition of osteogenic transdifferentiation and promotion of extracellular matrix stability

2024-08-30

Abstract excerpt

Vascular calcification (VC), a common pathological condition, is a strong predictor of cardiovascular events and associated mortality. Development and progression of VC heavily rely on vascular smooth muscle cells (VSMCs) and are closely related to oxidative stress, inflammation, and remodelling of extracellular matrix (ECM). Copper (Cu), an essential microelement, participates in these processes, however its invo...

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Literature Corpus work: 9d0541d8-19d0-554b-8051-7cd3c6d42cc0
DOI: 10.1101/2024.08.30.610428

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