Article
Initiating-clone analysis in patients with acute myeloid leukemia secondary to essential thrombocythemia.
Scientific reports - 10 Jul 2024
Ushijima Yoko, Naruse Seara, Ishikawa Yuichi, Kawashima Naomi, Sanada Masashi, Nakashima Marie, Kim Jeong Hui, Terakura Seitaro, Kihara Rika, Watamoto Koichi, Nishiyama Takahiro, Kitamura Kunio, Matsushita Tadashi, Kiyoi Hitoshi
Abstract excerpt
Most of essential thrombocythemia (ET) patients have the clone harboring a mutation in one of the JAK2, CALR, or MPL gene, and these clones generally acquire additional mutations at transformation to acute myeloid leukemia (AML). However, the proliferation of triple-negative clones has sometimes been observed at AML transformation. To clarify the clonal evolution of ET to AML, we analyzed paired samples at ET and...
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