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Article

Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2024

Gao Yaqing, Amin Najaf, van Duijn Cornelia, Littlejohns Thomas J

Abstract excerpt

INTRODUCTION: Higher neuroticism might be associated with dementia risk. Here we investigated modification by genetic predisposition to dementia, mediation by mental health and vascular conditions, neuroimaging outcomes, and cognitive function. METHODS: Cox proportional-hazards models were used to assess the association between neuroticism score and incident dementia over up to 15 years in 1,74,164 participants....

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Source

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Identifiers

PMID: 38984680
DOI: 10.1002/alz.14071
PMCID: PMC11350007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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