Genotype-specific Expression of Uncle Fester Suggests a Role in Allorecognition Education in a Basal Chordate.

Abstract excerpt

Histocompatibility is the ability to discriminate between self and non-self tissues, and has been described in species throughout the metazoa. Despite its universal presence, histocompatibility genes utilized by different phyla are unique-those found in sponges, cnidarians, ascidians, and vertebrates are not orthologous. Thus, the origins of these sophisticated recognition systems, and any potential functional...

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