Article
Molecular mechanisms of allorecognition in a basal chordate.
Seminars in immunology - 1 Feb 2010
McKitrick Tanya R, De Tomaso Anthony W
Abstract excerpt
Allorecognition has been described in many metazoan phyla, from the sponges to the mammals. In vertebrates, allorecognition is a result of a MHC-based recognition event central to adaptive immunity. However, the origin of the adaptive immune system and the potential relationship to more primitive allorecognition systems is unclear. The colonial ascidian, Botryllus schlosseri, has been used as a model organism for...
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