Article
Identification of a colonial chordate histocompatibility gene.
Science (New York, N.Y.) - 26 Jul 2013
Voskoboynik Ayelet, Newman Aaron M, Corey Daniel M, Sahoo Debashis, Pushkarev Dmitry, Neff Norma F, Passarelli Benedetto, Koh Winston, Ishizuka Katherine J, Palmeri Karla J, Dimov Ivan K, Keasar Chen, Fan H Christina, Mantalas Gary L, Sinha Rahul, Penland Lolita, Quake Stephen R, Weissman Irving L
Abstract excerpt
Histocompatibility is the basis by which multicellular organisms of the same species distinguish self from nonself. Relatively little is known about the mechanisms underlying histocompatibility reactions in lower organisms. Botryllus schlosseri is a colonial urochordate, a sister group of vertebrates, that exhibits a genetically determined natural transplantation reaction, whereby self-recognition between...
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