Article
Circulating KRAS G12D but not G12V is associated with survival in metastatic pancreatic ductal adenocarcinoma.
Nature communications - 9 Jul 2024
Till Jacob E, McDaniel Lee, Chang Changgee, Long Qi, Pfeiffer Shannon M, Lyman Jaclyn P, Padrón Lacey J, Maurer Deena M, Yu Jia Xin, Spencer Christine N, Gherardini Pier Federico, Da Silva Diane M, LaVallee Theresa M, Abbott Charles, Chen Richard O, Boyle Sean M, Bhagwat Neha, Cannas Samuele, Sagreiya Hersh, Li Wenrui, Yee Stephanie S, Abdalla Aseel, Wang Zhuoyang, Yin Melinda, Ballinger Dominique, Wissel Paul, Eads Jennifer, Karasic Thomas, Schneider Charles, O'Dwyer Peter, Teitelbaum Ursina, Reiss Kim A, Rahma Osama E, Fisher George A, Ko Andrew H, Wainberg Zev A, Wolff Robert A, O'Reilly Eileen M, O'Hara Mark H, Cabanski Christopher R, Vonderheide Robert H, Carpenter Erica L
Abstract excerpt
While high circulating tumor DNA (ctDNA) levels are associated with poor survival for multiple cancers, variant-specific differences in the association of ctDNA levels and survival have not been examined. Here we investigate KRAS ctDNA (ctKRAS) variant-specific associations with overall and progression-free survival (OS/PFS) in first-line metastatic pancreatic ductal adenocarcinoma (mPDAC) for patients receiving...
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