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Article

Peripheral and Portal Venous KRAS ctDNA Detection as Independent Prognostic Markers of Early Tumor Recurrence in Pancreatic Ductal Adenocarcinoma.

Clinical chemistry - 1 Mar 2023

Nitschke Christine, Markmann Benedikt, Walter Philipp, Badbaran Anita, Tölle Marie, Kropidlowski Jolanthe, Belloum Yassine, Goetz Mara R, Bardenhagen Jan, Stern Louisa, Tintelnot Joseph, Schönlein Martin, Sinn Marianne, van der Leest Paul, Simon Ronald, Heumann Asmus, Izbicki Jakob R, Pantel Klaus, Wikman Harriet, Uzunoglu Faik G

Abstract excerpt

BACKGROUND: KRAS circulating tumor DNA (ctDNA) has shown biomarker potential for pancreatic ductal adenocarcinoma (PDAC) but has not been applied in clinical routine yet. We aim to improve clinical applicability of ctDNA detection in PDAC and to study the impact of blood-draw site and time point on the detectability and prognostic role of KRAS mutations. METHODS: 221 blood samples from 108 PDAC patients (65...

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Identifiers

PMID: 36644936
DOI: 10.1093/clinchem/hvac214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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