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Article

Possible correlation between KRIT1 variant and non-atherosclerotic vasculopathy resulting in ischemic stroke.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 13 Jan 2026

Marzioglu Ozdemir Ebru, Ozdemir Gokhan

Abstract excerpt

OBJECTIVE: To provide the first instance of ischemic stroke attributable to vasculopathy linked to a pathogenic variant in the Krev interaction trapped-1 (KRIT1) gene, which has previously been recognized solely for its involvement in cerebral cavernous malformations (CCMs). METHODS: A 23-year-old male patient with acute ischemic stroke and a familial history of early-onset stroke underwent evaluation using...

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PMID: 41528497
DOI: 10.1007/s10072-025-08628-3

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