Using T4 genetics and Laemmli's development of high-resolution SDS gel electrophoresis to reveal structural protein interactions controlling protein folding and phage self-assembly.

Abstract excerpt

One of the most transformative experimental techniques in the rise of modern molecular biology and biochemistry was the development of high-resolution sodium dodecyl sulfate polyacrylamide gel electrophoresis, which allowed separation of proteins-including structural proteins-in complex mixtures according to their molecular weights. Its development was intimately tied to investigations of the control of virus...

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