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Article

Simulated complexes formed from a set of postsynaptic proteins suggest a localised effect of a hypomorphic Shank mutation.

BMC neuroscience - 6 Jul 2024

Miski Marcell, Weber Áron, Fekete-Molnár Krisztina, Keömley-Horváth Bence Márk, Csikász-Nagy Attila, Gáspári Zoltán

Abstract excerpt

BACKGROUND: The postsynaptic density is an elaborate protein network beneath the postsynaptic membrane involved in the molecular processes underlying learning and memory. The postsynaptic density is built up from the same major proteins but its exact composition and organization differs between synapses. Mutations perturbing protein: protein interactions generally occurring in this network might lead to effects...

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Identifiers

PMID: 38971749
DOI: 10.1186/s12868-024-00880-1
PMCID: PMC11227168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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