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Article

The genome- and system-wide response of DNA methylation to early life adversity and its implication on mental health.

Canadian journal of psychiatry. Revue canadienne de psychiatrie - 1 Dec 2013

Szyf Moshe

Abstract excerpt

Early life adversity is associated with long-tem impacts on behaviour and physical and mental health. The mechanisms mediating the impact of early life environment on the phenotype are proposed to involve a change in the state of deoxyribonucleic acid (DNA) methylation and, as a consequence, in the stable programming of gene expression. Recent studies suggest that the changes in DNA methylation affect broad...

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Identifiers

PMID: 24331290
DOI: 10.1177/070674371305801208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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