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Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

1 Jan 2021

Abstract excerpt

DNA methylation (DNAm) is known to play a pivotal role in childhood health and development, but a comprehensive characterization of genome-wide DNAm trajectories across this age period is currently lacking. We have therefore performed a series of epigenome-wide association studies in 5019 blood samples collected at multiple time-points from birth to late adolescence from 2348 participants of two large independent...

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PMID: 33450751
DOI: 10.1093/hmg/ddaa280

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