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Association of NLRP3 and IL-4 VNTR polymorphisms and genetic susceptibility to preeclampsia: A case-control study.

Pregnancy hypertension - 1 Sept 2024

Che Mingxuan, Xu Yinglei, Zang Yucui, Zhang Ru, Hu Jian, Liu Shiguo, Zhang Jidong

Abstract excerpt

INTRODUCTION: Abnormalities in the maternal immune system and insufficient gestational immune tolerance may significantly contribute to the development of preeclampsia (PE). The NLR family pyrin domain containing 3 (NLRP3) functions as a pattern recognition receptor that identifies pathogen-associated molecular patterns. Interleukin-4 (IL-4) is a potent anti-inflammatory cytokine that modulates the immune...

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PMID: 38959653
DOI: 10.1016/j.preghy.2024.101142

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