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HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy

2 Jul 2024

Abstract excerpt

The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral landscape, which have been predominantly conducted in males in the United States and Europe living with HIV-1 subtype B, have revealed that most proviruses that persist during antiretroviral therapy (ART) are defective. In contrast, less is known about proviral...

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PMID: 38956017
DOI: 10.1038/s41467-024-48985-9

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