Article
Prevalence and clinical impacts of HIV-1 intersubtype recombinants in Uganda revealed by near-full-genome population and deep sequencing approaches.
AIDS (London, England) - 13 Nov 2017
Lee Guinevere Q, Bangsberg David R, Mo Theresa, Lachowski Chris, Brumme Chanson J, Zhang Wendy, Lima Viviane D, Boum Yap, Mwebesa Bosco Bwana, Muzoora Conrad, Andia Iren, Mbalibulha Yona, Kembabazi Annet, Carroll Ryan, Siedner Mark J, Haberer Jessica E, Mocello A Rain, Kigozi Simone H, Hunt Peter W, Martin Jeffrey N, Harrigan P Richard
Abstract excerpt
OBJECTIVES: HIV-1 subtypes A1 and D cocirculate in a rural community in Mbarara, Uganda. This study examines HIV-1 intersubtype recombination in this community under a full-genome sequencing context. We aim to estimate prevalence, examine time trends, and test for clinical correlates and outcomes associated with intersubtype recombinants. METHODS: Near-full-genome HIV-1 Sanger sequence data were collected from...
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