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Article

Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA

22 Dec 2020

Abstract excerpt

The intact proviral DNA assay (IPDA) and quadruplex PCR (Q4PCR) represent major advances in accurately quantifying and characterizing the replication-competent HIV reservoir. This study compares the two novel approaches for measuring intact HIV proviral DNA in samples from 39 antiretroviral therapy (ART)-suppressed people living with HIV, thereby informing ongoing efforts to deplete the HIV reservoir in...

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PMID: 33361426
DOI: 10.1128/jvi.01986-20

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