Article
The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity, and Cardiac Function in Zebrafish.
The Journal of biological chemistry - 23 Dec 2016
Berchtold Martin W, Zacharias Triantafyllos, Kulej Katarzyna, Wang Kevin, Torggler Raffaela, Jespersen Thomas, Chen Jau-Nian, Larsen Martin R, la Cour Jonas M
Abstract excerpt
Calmodulin (CaM) is a Ca2+ binding protein modulating multiple targets, several of which are associated with cardiac pathophysiology. Recently, CaM mutations were linked to heart arrhythmia. CaM is crucial for cell growth and viability, yet the effect of the arrhythmogenic CaM mutations on cell viability, as well as heart rhythm, remains unknown, and only a few targets with relevance for heart physiology have...
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