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A pilot study of the role of the BDNF Val66Met polymorphism in response to exercise-augmented exposure therapy for posttraumatic stress disorder.

Psychoneuroendocrinology - 1 Sept 2024

Bryant Richard A, Dawson Katie S, Azevedo Suzanna, Yadav Srishti, Cahill Catherine, Kenny Lucy, Maccallum Fiona, Tran Jenny, Rawson Natasha, Tockar Julia, Garber Benjamin, Keyan Dharani

Abstract excerpt

Brain-Derived Neurotrophic Factor (BDNF) is implicated in extinction learning, which is a primary mechanism of exposure therapy for posttraumatic stress disorder (PTSD). Brief aerobic exercise has been shown to promote BDNF release and augment extinction learning. On the premise that the Val allele of the BDNF Val66Met polymorphism facilitates greater release of BDNF, this study examined the extent to which the...

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Source

Identifiers

PMID: 38943720
DOI: 10.1016/j.psyneuen.2024.107106

Genes

BDNF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A pilot study of the role of the BDNF Val66Met polymorphism in response to exercise-augmented exposure therapy for posttraumatic stress disorder.PMID 38943720Read ↗

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