Article
The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.
Communications biology - 28 Jun 2024
Carey Megan E, Thi Nguyen To Nguyen, Tran Do Hoang Nhu, Dyson Zoe A, Keane Jacqueline A, Pham Thanh Duy, Mylona Elli, Nair Satheesh, Chattaway Marie, Baker Stephen
Abstract excerpt
Antimicrobial resistance (AMR) poses a serious threat to the clinical management of typhoid fever. AMR in Salmonella Typhi (S. Typhi) is commonly associated with the H58 lineage, a lineage that arose comparatively recently before becoming globally disseminated. To better understand when and how H58 emerged and became dominant, we performed detailed phylogenetic analyses on contemporary genome sequences from S....
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