A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure.

doi:10.7554/eLife.14003

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Article

A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure.

eLife - 11 Mar 2016

Pham Thanh Duy, Karkey Abhilasha, Dongol Sabina, Ho Thi Nhan, Thompson Corinne N, Rabaa Maia A, Arjyal Amit, Holt Kathryn E, Wong Vanessa, Tran Vu Thieu Nga, Voong Vinh Phat, Ha Thanh Tuyen, Pradhan Ashish, Shrestha Saroj Kumar, Gajurel Damoder, Pickard Derek, Parry Christopher M, Dougan Gordon, Wolbers Marcel, Dolecek Christiane, Thwaites Guy E, Basnyat Buddha, Baker Stephen

Abstract excerpt

The interplay between bacterial antimicrobial susceptibility, phylogenetics and patient outcome is poorly understood. During a typhoid clinical treatment trial in Nepal, we observed several treatment failures and isolated highly fluoroquinolone-resistant Salmonella Typhi (S. Typhi). Seventy-eight S. Typhi isolates were genome sequenced and clinical observations, treatment failures and fever clearance times (FCTs)...

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PMID: 26974227
DOI: 10.7554/eLife.14003
PMCID: PMC4805543

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