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Article

Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study.

Annals of the rheumatic diseases - 1 Oct 2011

Livshits Gregory, Popham Maria, Malkin Ida, Sambrook Philip N, Macgregor Alex J, Spector Timothy, Williams Frances M K

Abstract excerpt

OBJECTIVE: Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population. MATERIAL AND METHODS: A cross-sectional study was conducted among 2256 women (371 and 698 monozygotic and dizygotic twin pairs and 29...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Cross-Sectional Studies
Diseases in Twins
Female
Genetic Predisposition to Disease
Humans
Intervertebral Disc Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Low Back Pain

Lumbar Vertebrae

Magnetic Resonance Imaging

Middle Aged

Overweight

Risk Factors

United Kingdom

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 21646416
DOI: 10.1136/ard.2010.137836
PMCID: PMC3171106

Genes

LBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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