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Article

Brain imaging-wide exploration of site-specific pain: genetic correlation and Mendelian randomization study.

Psychological medicine - 28 Jul 2026

Mao Weian, Ye Peipei, Wang Shuwei, Chen Mengchun, Lv Haiying, Yuan Shuai, Yan Fuhua, Yang Lili

Abstract excerpt

BACKGROUND: Observational studies have suggested that brain imaging-derived phenotypes (IDPs) may serve as specific markers of pain-related phenotypes and severity. However, the shared genetic architecture between pain and brain IDPs and their potential causal relationships remains unclear. METHODS: We applied linkage disequilibrium score regression and Mendelian randomization (MR) analyses to uncover genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42516085
DOI: 10.1017/S0033291726105091
PMCID: PMC13439259

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