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Article

BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.

Molecular oncology - 1 Jun 2013

Stordal Britta, Timms Kirsten, Farrelly Angela, Gallagher Danielle, Busschots Steven, Renaud Mickaël, Thery Julien, Williams Deborah, Potter Jennifer, Tran Thanh, Korpanty Greg, Cremona Mattia, Carey Mark, Li Jie, Li Yang, Aslan Ozlem, O'Leary John J, Mills Gordon B, Hennessy Bryan T

Abstract excerpt

Mutations in BRCA1/2 increase the risk of developing breast and ovarian cancer. Germline BRCA1/2 mutations occur in 8.6-13.7% of unselected epithelial ovarian cancers, somatic mutations are also frequent. BRCA1/2 mutated or dysfunctional cells may be sensitive to PARP inhibition by synthetic lethality. The aim of this study is to comprehensively characterise the BRCA1/2 status of a large panel of ovarian cancer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Drug Resistance, Neoplasm

Share to Loss of Heterozygosity

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Source

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Identifiers

PMID: 23415752
DOI: 10.1016/j.molonc.2012.12.007
PMCID: PMC4106023

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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