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Article

Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major.

Haematologica - 1 Sept 2009

Andreani Marco, Radio Francesca Clementina, Testi Manuela, De Bernardo Carmelilia, Troiano Maria, Majore Silvia, Bertucci Pierfrancesco, Polchi Paola, Rosati Renata, Grammatico Paola

Abstract excerpt

Hepcidin is a 25-amino acid peptide, derived from cleavage of an 84 amino acid pro-peptide produced predominantly by hepatocytes. This molecule, encoded by the hepcidin antimicrobial peptide (HAMP) gene shows structural and functional properties consistent with a role in innate immunity. Moreover, as demonstrated in mice and humans, hepcidin is a major regulator of iron metabolism, and acts by binding to...

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Topics

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Share to Antimicrobial Cationic Peptides
Share to beta-Thalassemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Transfusion

Share to Hepcidins

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 19734422
DOI: 10.3324/haematol.2009.006270
PMCID: PMC2738723

Genes

HAMP
HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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