Hepcidin gene polymorphisms and iron overload in β-thalassemia major patients refractory to iron chelating therapy.

Abstract excerpt

BACKGROUND: β Thalassemia is one of the most common groups of hereditary haemoglobinopathies. Affected people with thalassemia major are dependent on regular blood transfusion which on the long term leads to iron overload. Hepcidin is a peptide hormone and an important regulator of iron homeostasis, especially in thalassemia. Expression of this hormone is influenced by polymorphisms within the hepcidin gene,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to beta-Thalassemia
• Share to Hepcidins
• Share to Homeostasis