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Article

Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome.

Trends in molecular medicine - 1 Feb 2020

Lee Sarah E, Duran-Martinez Monica, Khantsis Sabina, Bianchi Diana W, Guedj Faycal

Abstract excerpt

While preclinical studies have reported improvement of behavioral deficits in the Ts65Dn mouse model of Down syndrome (DS), translation to human clinical trials to improve cognition in individuals with DS has had a poor success record. Timing of the intervention, choice of animal models, strategy for drug selection, and lack of translational endpoints between animals and humans contributed to prior failures of...

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Identifiers

PMID: 31706840
DOI: 10.1016/j.molmed.2019.10.001
PMCID: PMC6997046

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