Article
Identification of MTHFD2 as a prognostic biomarker and ferroptosis regulator in triple-negative breast cancer
16 Jan 2023
Abstract excerpt
Background Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial bifunctional enzyme encoded in the nucleus. It plays a significant role in the regulation of glucose, nucleic acid, and folate metabolism, and maintains redox balance in the cells. The present study aimed at elucidating the potential function and mechanisms of MTHFD2 and explored the correlation between ferroptosis and MTHFD2 in...
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