Article
Multifunctional Cell Regulation Activities of the Mussel Lectin SeviL: Induction of Macrophage Polarization toward the M1 Functional Phenotype.
Marine drugs - 11 Jun 2024
Fujii Yuki, Kamata Kenichi, Gerdol Marco, Hasan Imtiaj, Rajia Sultana, Kawsar Sarkar M A, Padma Somrita, Chatterjee Bishnu Pada, Ohkawa Mayuka, Ishiwata Ryuya, Yoshimoto Suzuna, Yamada Masao, Matsuzaki Namiho, Yamamoto Keita, Niimi Yuka, Miyanishi Nobumitsu, Konno Masamitsu, Pallavicini Alberto, Kawasaki Tatsuya, Ogawa Yukiko, Ozeki Yasuhiro, Fujita Hideaki
Abstract excerpt
SeviL, a galactoside-binding lectin previously isolated from the mussel Mytilisepta virgata, was demonstrated to trigger apoptosis in HeLa ovarian cancer cells. Here, we show that this lectin can promote the polarization of macrophage cell lines toward an M1 functional phenotype at low concentrations. The administration of SeviL to monocyte and basophil cell lines reduced their growth in a dose-dependent manner....
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