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Physiological regulation of neuronal Wnt activity is essential for TDP-43 localization and function

25 Jun 2024

Abstract excerpt

Nuclear exclusion of the RNA- and DNA-binding protein TDP-43 can induce neurodegeneration in different diseases. Diverse processes have been implicated to influence TDP-43 mislocalization, including disrupted nucleocytoplasmic transport (NCT); however, the physiological pathways that normally ensure TDP-43 nuclear localization are unclear. The six-transmembrane enzyme glycerophosphodiester phosphodiesterase 2...

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PMID: 38918634
DOI: 10.1038/s44318-024-00156-8

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