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Article

Regulation of Glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons

2025-09-25

Abstract excerpt

Abnormalities in TDP-43 (Transactive response DNA-binding protein 43kDa) localization and function span multiple neurodegenerative diseases and are implicated in driving neuronal degeneration and loss. Nuclear pore complex (NPC) abnormalities and disrupted nucleocytoplasmic trafficking (NCT) contribute to TDP-43 mislocalization, but how these cellular changes are initiated in disease is unclear. Glycerophosphodies...

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Identifiers and source

Literature Corpus work
7ad27c27-255b-5315-8b69-bb66aeb19c3d
DOI
10.1101/2025.09.24.678385
Open publication

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Regulation of Glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neuronsDOI 10.1101/2025.09.24.678385
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