Article

Identity-by-descent captures shared environmental factors at biobank scale

2025-05-08

Abstract excerpt

Genealogical ties leave traces beyond shared genetic material: relatives tend to share environmental exposures and cultural practices that persist across generations. Using genomic and electronic health record data from 13,143 individuals in the Biorepository for Integrative Genomics, we applied a hierarchical community detection algorithm to group individuals into four major communities and 17 subcommunities base...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 888a6ba4-9040-5963-9d8a-ef70febc7701
DOI: 10.1101/2025.05.03.652048

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identity-by-descent captures shared environmental factors at biobank scaleDOI 10.1101/2025.05.03.652048Read

Towards a fine-scale population health monitoring systemSemantic proximity Read

Health care utilization of fine-scale identity by descent clusters in a Los Angeles biobankSemantic proximity Read

A Scalable Framework to Integrate Social Determinants of Health into Disease Risk Models using Biobank Survey DataSemantic proximity Read

Integrating social determinants of health and genetic risk in disease risk models.Semantic proximity Read

Decoding Genetics, Ancestry, and Geospatial Context for Precision HealthSemantic proximity Read

The Biorepository and Integrative Genomics resource for inclusive genomics: insights from a diverse pediatric and admixed cohortSemantic proximity Read

Deconvoluting complex correlates of COVID19 severity with local ancestry inference and viral phylodynamics: Results of a multiomic pandemic tracking strategySemantic proximity Read

Linking Place-Based Exposures and Genomics to understand Human PhenotypesSemantic proximity Read

Linking Place-Based Exposures and Genomics to understand Human PhenotypesSemantic proximity Read

Blood-based epigenome-wide analyses on the prevalence and incidence of nineteen common disease statesSemantic proximity Read

Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan.Semantic proximity Read

Multi-ancestry gene-trait connection landscape using electronic health record (EHR) linked biobank dataSemantic proximity Read