Article
Vibrio cholerae O1 experiences mild bottlenecks through the gastrointestinal tract in some but not all cholera patients.
Microbiology spectrum - 6 Aug 2024
Lypaczewski Patrick, Chac Denise, Dunmire Chelsea N, Tandoc Kristine M, Chowdhury Fahima, Khan Ashraful I, Bhuiyan Taufiqur R, Harris Jason B, LaRocque Regina C, Calderwood Stephen B, Ryan Edward T, Qadri Firdausi, Shapiro B Jesse, Weil Ana A
Abstract excerpt
Vibrio cholerae O1 causes the diarrheal disease cholera, and the small intestine is the site of active infection. During cholera, cholera toxin is secreted from V. cholerae and induces a massive fluid influx into the small intestine, which causes vomiting and diarrhea. Typically, V. cholerae genomes are sequenced from bacteria passed in stool, but rarely from vomit, a fluid that may more closely represents the...
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