Article
Vibrio cholerae genomic diversity within and between patients.
Microbial genomics - 1 Dec 2017
Levade Inès, Terrat Yves, Leducq Jean-Baptiste, Weil Ana A, Mayo-Smith Leslie M, Chowdhury Fahima, Khan Ashraful I, Boncy Jacques, Buteau Josiane, Ivers Louise C, Ryan Edward T, Charles Richelle C, Calderwood Stephen B, Qadri Firdausi, Harris Jason B, LaRocque Regina C, Shapiro B Jesse
Abstract excerpt
Cholera is a severe, water-borne diarrhoeal disease caused by toxin-producing strains of the bacterium Vibrio cholerae. Comparative genomics has revealed 'waves' of cholera transmission and evolution, in which clones are successively replaced over decades and centuries. However, the extent of V. cholerae genetic diversity within an epidemic or even within an individual patient is poorly understood. Here, we...
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