Article
Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen.
Current topics in microbiology and immunology - 1 Jan 2014
Robins William P, Mekalanos John J
Abstract excerpt
Modern genomic and bioinformatic approaches have been applied to interrogate the V. cholerae genome, the role of genomic elements in cholera disease, and the origin, relatedness, and dissemination of epidemic strains. A universal attribute of choleragenic strains includes a repertoire of pathogenicity islands and virulence genes, namely the CTXϕ prophage and Toxin Co-regulated Pilus (TCP) in addition to other...
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