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Staphylococcus aureus persistence in osteocytes: weathering the storm of antibiotics and autophagy/xenophagy

10 Jun 2024

Abstract excerpt

Staphylococcus aureus is a major causative pathogen of osteomyelitis. Intracellular infections of resident bone cells including osteocytes can persist despite gold-standard clinical intervention. The mechanisms by which intracellular S. aureus evades antibiotic therapy are unknown. In this study, we utilised an in vitro S. aureus infection model of human osteocytes to investigate whether antibiotic-mediated...

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PMID: 38915921
DOI: 10.3389/fcimb.2024.1403289

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