Cytotoxic and genotoxic effects induced by stannous chloride associated to nuclear medicine kits.

doi:10.1016/j.nucmedbio.2006.07.008

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Article

Cytotoxic and genotoxic effects induced by stannous chloride associated to nuclear medicine kits.

Nuclear medicine and biology - 1 Oct 2006

Guedes Anderson P, Cardoso Valbert N, De Mattos Jose C P, Dantas Flavio J S, Matos Vanessa C, Silva Josiane C F, Bezerra Roberto J A C, Caldeira-de-Araujo Adriano

Abstract excerpt

At present, more than 75% of routine nuclear medicine diagnostic procedures use technetium-99m (99mTc). The binding between 99mTc and the drug to obtain the radiopharmaceutical needs a reducing agent, with stannous chloride (SnCl2) being one of the most used. There are controversies about the cytotoxic, genotoxic and mutagenic effects of SnCl2 in the literature. Thus, the approaches below were used to better...

Topics

Cell Survival
DNA, Bacterial
Dose-Response Relationship, Drug
Escherichia coli
Mutagenicity Tests
Mutation
Nuclear Medicine
Reagent Kits, Diagnostic
Tin Compounds

Source

Open in PubMed

Identifiers

PMID: 17045172
DOI: 10.1016/j.nucmedbio.2006.07.008

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