Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WLS-Wnt signaling promotes neuroendocrine prostate cancer

31 Dec 2020

Abstract excerpt

Neuroendocrine prostate cancer (NEPC) is a lethal prostate cancer subtype arising as a consequence of more potent androgen receptor (AR) targeting in castration-resistant prostate cancer (CRPC). Its molecular pathogenesis remains elusive. Here, we report that the Wnt secretion mediator Wntless (WLS) is a major driver of NEPC and aggressive tumor growth in vitro and in vivo . Mechanistic studies showed that WLS is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Prostate Cancer Treatment and Research
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33437943
DOI: 10.1016/j.isci.2020.101970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WLS-Wnt signaling promotes neuroendocrine prostate cancerPMID 33437943Read ↗

Yin Yang 1 promotes the neuroendocrine differentiation of prostate cancer cells via the non‐canonical WNT pathway (FYN/STAT3)Semantic proximity Read ↗

Characterization of Wnt Signaling Pathway Aberrations in Metastatic Prostate Cancer.Semantic proximity Read ↗

Combination therapies with Wnt signaling inhibition: A better choice for prostate cancer treatmentSemantic proximity Read ↗

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineageSemantic proximity Read ↗

Establishment of a neuroendocrine prostate cancer model driven by the RNA splicing factor SRRM4Semantic proximity Read ↗

Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancerSemantic proximity Read ↗

Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancerSemantic proximity Read ↗

A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene networkSemantic proximity Read ↗

Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 ExpressionSemantic proximity Read ↗

A novel REST-regulated lncRNA PCAT-NE1 induces neuroendocrine differentiation in castration-resistant prostate cancerSemantic proximity Read ↗

Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancerSemantic proximity Read ↗

Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.