Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating the Correlation between Genotypes and Hepatic Protein Expression of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 Using Postmortem Tissue from a Danish Population.

Drug metabolism and disposition: the biological fate of chemicals - 14 Aug 2024

Pedersen Kata W, Andersen Jeppe D, Hansen Jakob, Børsting Claus, Banner Jytte, Hasselstrøm Jørgen B, Jornil Jakob R

Abstract excerpt

The cytochrome P450 (CYP) family of enzymes plays a central role in the metabolism of many drugs. CYP genes are highly polymorphic, which is known to affect protein levels, but for some low frequent CYP genotypes the correlation between genotype and CYP protein expression is less established. In this study, we determined the CYP2C9, CYP2C19, CYP2D6, and CYP3A5 genotypes of 250 Danish individuals included in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autopsy
Share to Cytochrome P-450 CYP2C19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Cytochrome P-450 CYP2D6

Share to Cytochrome P-450 CYP3A

Share to Denmark

Share to Proteomics

Source

Identifiers

PMID: 38906700
DOI: 10.1124/dmd.124.001692

Genes

CYP2C19
CYP3A5
CYP2C9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the Correlation between Genotypes and Hepatic Protein Expression of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 Using Postmortem Tissue from a Danish Population.PMID 38906700Read ↗

Frequencies of Genetic Polymorphisms of Clinically Relevant Gene-Drug Pairs in a German Psychiatric Inpatient Population.Semantic proximity Read ↗

Cytochrome P4502C9 (CYP2C9) genotypes in a Nordic population in Denmark.Semantic proximity Read ↗

Distribution of the cytochrome P450 *alleles for CYP2C9 and CYP2C19 in a cohort of the Danish Blood Donor Study determined by using the Illumina Infinium Global Screening Array.Semantic proximity Read ↗

Five genetic polymorphisms of cytochrome P450 enzymes in the Czech non-Roma and Czech Roma population samples.Semantic proximity Read ↗

Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests.Semantic proximity Read ↗

Low frequency of defective alleles of cytochrome P450 enzymes 2C19 and 2D6 in the Turkish population.Semantic proximity Read ↗

Genetic variations in NADPH-CYP450 oxidoreductase in a Czech Slavic cohort.Semantic proximity Read ↗

Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization.Semantic proximity Read ↗

Physiological Content and Intrinsic Activities of 10 Cytochrome P450 Isoforms in Human Normal Liver Microsomes.Semantic proximity Read ↗

Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting.Semantic proximity Read ↗

Genotyping of cytochrome p450 isoform genes is useful for forensic identification of cadaver.Semantic proximity Read ↗

Site-Directed Mutagenesis of Cytochrome P450 2D6 and 2C19 Enzymes: Expression and Spectral Characterization of Naturally Occurring Allelic Variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.