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Article

Structure and Function of Filamin C in the Muscle Z-Disc.

International journal of molecular sciences - 13 Apr 2020

Mao Zhenfeng, Nakamura Fumihiko

Abstract excerpt

Filamin C (FLNC) is one of three filamin proteins (Filamin A (FLNA), Filamin B (FLNB), and FLNC) that cross-link actin filaments and interact with numerous binding partners. FLNC consists of a N-terminal actin-binding domain followed by 24 immunoglobulin-like repeats with two intervening calpain-sensitive hinges separating R15 and R16 (hinge 1) and R23 and R24 (hinge-2). The FLNC subunit is dimerized through R24...

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Identifiers

PMID: 32295012
DOI: 10.3390/ijms21082696
PMCID: PMC7216277

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