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Article

Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.

Human molecular genetics - 1 Jul 2016

Leber Yvonne, Ruparelia Avnika A, Kirfel Gregor, van der Ven Peter F M, Hoffmann Bernd, Merkel Rudolf, Bryson-Richardson Robert J, Fürst Dieter O

Abstract excerpt

Filamin c (FLNc) is a large dimeric actin-binding protein located at premyofibrils, myofibrillar Z-discs and myofibrillar attachment sites of striated muscle cells, where it is involved in mechanical stabilization, mechanosensation and intracellular signaling. Mutations in the gene encoding FLNc give rise to skeletal muscle diseases and cardiomyopathies. Here, we demonstrate by fluorescence recovery after...

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Identifiers

PMID: 27206985
DOI: 10.1093/hmg/ddw135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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