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Article

Kismet/CHD7/CHD8 affects gut microbiota, mechanics, and the gut-brain axis in Drosophila melanogaster.

Biophysical journal - 18 Mar 2025

Niosi Angelo, Võ Nguyên Henry, Sundaramurthy Punithavathi, Welch Chloe, Penn Aliyah, Yuldasheva Yelena, Alfareh Adam, Rausch Kaitlyn, Amin-Rahbar Takhmina, Cavanaugh Jeffery, Yadav Prince, Peterson Stephanie, Brown Raina, Hu Alain, Ardon-Castro Any, Nguyen Darren, Crawford Robert, Lee Wendy, Morris Eliza J, Jensen Mikkel Herholdt, Mulligan Kimberly

Abstract excerpt

The gut microbiome affects brain and neuronal development and may contribute to the pathophysiology of neurodevelopmental disorders. However, it is unclear how risk genes associated with such disorders affect gut physiology in a manner that could impact microbial colonization and how the mechanical properties of the gut tissue might play a role in gut-brain bidirectional communication. To address this, we used...

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Identifiers

PMID: 38902926
DOI: 10.1016/j.bpj.2024.06.016
PMCID: PMC11947469

Genes

CHD7
CHD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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