Article
Dietary vitamin D intake and risk of colorectal cancer according to vitamin D receptor expression in tumors and their surrounding stroma.
Journal of gastroenterology - 1 Sept 2024
Nakano Shiori, Yamaji Taiki, Hidaka Akihisa, Shimazu Taichi, Shiraishi Kouya, Kuchiba Aya, Saito Masahiro, Kunishima Fumihito, Nakaza Ryouji, Kohno Takashi, Sawada Norie, Inoue Manami, Tsugane Shoichiro, Iwasaki Motoki
Abstract excerpt
BACKGROUND: Colorectal Cancer (CRC) has been molecularly classified into several subtypes according to tumor, stromal, and immune components. Here, we investigated whether the preventive effect of vitamin D on CRC varies with subtypes defined by Vitamin D receptor (VDR) expression in tumors and their surrounding stroma, along with the association of somatic mutations in CRC. METHODS: In a population-based...
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