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Characteristics of Chinese breast cancer patients with double heterozygosity for BRCA1 and BRCA2 germline pathogenic variants.

Breast cancer research and treatment - 1 Nov 2024

Wen Song, Zhang Meng, Chen Jiuan, Hu Li, Sun Jie, Yao Lu, Xu Ye, Zhang Juan, Xie Yuntao

Abstract excerpt

PURPOSE: Despite of very rare, breast cancer patients with double heterozygosity (DH) variants in BRCA1 and BRCA2 genes have been identified in other ethnic groups and seem to be associated with distinctive phenotypes. However, little is known about the frequency and clinical characteristics of Chinese breast cancer patients with BRCA1/2 DH variants. METHODS: Four hundred and eleven unrelated patients with BRCA1...

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PMID: 38900213
DOI: 10.1007/s10549-024-07409-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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