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Article

Clinicopathological Characterization of Double Heterozygosity for BRCA1 and BRCA2 Variants in Korean Breast Cancer Patients.

Cancer research and treatment - 1 Jul 2022

Bang Yoon Ju, Kwon Won Kyung, Nam Seok Jin, Kim Seok Won, Chae Byung-Joo, Lee Se Kyung, Ryu Jai Min, Kim Jong-Won, Yu Jonghan, Lee Jeong Eon

Abstract excerpt

PURPOSE: Double heterozygosity (DH) for BRCA1 and BRCA2 variant is very rare with only a few cases reported, and most those in Caucasians. In this article, we present seven unrelated cases of DH for BRCA1/2 identified from a single institution in Korea, and describe the characteristics and phenotype of DH individuals compared to those with a single BRCA variant. MATERIALS AND METHODS: This study included 27,678...

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Identifiers

PMID: 34645131
DOI: 10.4143/crt.2021.791
PMCID: PMC9296941

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