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Article

Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD.

International journal of molecular sciences - 25 Jul 2022

Peter Antonia Sophia, Grüner Eva, Socher Eileen, Fraedrich Kirsten, Richel Elie, Mueller-Schmucker Sandra, Cordsmeier Arne, Ensser Armin, Sticht Heinrich, Überla Klaus

Abstract excerpt

Mutations in the spike protein of SARS-CoV-2 can lead to evasion from neutralizing antibodies and affect the efficacy of passive and active immunization strategies. Immunization of mice harboring an entire set of human immunoglobulin variable region gene segments allowed to identify nine neutralizing monoclonal antibodies, which either belong to a cluster of clonally related RBD or NTD binding antibodies. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35897753
DOI: 10.3390/ijms23158177
PMCID: PMC9332373

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