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Multiscale topology classifies cells in subcellular spatial transcriptomics

19 Jun 2024

Abstract excerpt

Abstract Spatial transcriptomics measures in situ gene expression at millions of locations within a tissue 1 , hitherto with some trade-off between transcriptome depth, spatial resolution and sample size 2 . Although integration of image-based segmentation has enabled impactful work in this context, it is limited by imaging quality and tissue heterogeneity. By contrast, recent array-based technologies offer the...

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PMID: 38898271
DOI: 10.1038/s41586-024-07563-1

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